Schizophrenia is a brain disease that makes the patient to have a split of mind. The patient sometimes behaves in normal manner and sometimes abnormally. The cause of this psychotic problem is associated with thalamus where the glutamate plays a major role in brain processes.
The depletion of glutamate affects the brain by lowering slowing the work of NMDA (Harrison, 2008). The receptors of metabotropic glutamate are found in brain regions that are associated with schizophrenia and they interfere with glutamate release in a slow manner. Psychosis is a major phenomenon that is associated with schizophrenia. Some of the symptoms of schizophrenia include abolition, emotional flattening and anhedonia and all theses lead to declination of cognitive functions in the patients and affective manifestations. The psychotic problem causes hallucinations, and illusion in thinking. Therefore, the study metabotropic glutamate helps to unravel the phenomena of schizophrenia, (Harrison, 2008).